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Faster clot-busting drug works as well as traditional drug for stroke
– A “clot-busting” drug recently approved to treat acute ischemic strokes (AIS) that can be delivered quickly works as well as a decades-old medication used by most hospitals in the U.S. and could hold significant advantages for some patients, a study led by a UT Southwestern Medical Center researcher shows. The findings, published in JAMA Network Open, could encourage more hospitals to use the newer drug, tenecteplase.
Neurostimulation shows promise as potential Alzheimer’s treatment
Repeated sessions of electrical stimulation to brain networks associated with memory improved verbal learning in some Alzheimer’s disease patients for up to eight weeks in a preliminary trial led by UT Southwestern Medical Center researchers. The findings, published in The Journal of Prevention of Alzheimer’s Disease, indicate that while future trials are needed, neurostimulation shows early promise as a treatment for Alzheimer’s and other neurodegenerative disorders, such as Lewy body dementia.
UTSW researchers use focused ultrasound to identify stroke biomarkers
A molecule called glial fibrillary acidic protein (GFAP) rose significantly in the blood of patients who underwent high-intensity focused ultrasound (HIFU), a procedure that is used to treat tremors and causes damage similar to a small stroke, UT Southwestern Medical Center scientists discovered in a new study. Their findings, published in Brain Communications, reveal a potential biomarker for stroke and could eventually lead to blood tests that quickly diagnose brain injuries.
Researchers make molecular connection between blindness, dementia
Researchers at UT Southwestern Medical Center have linked blindness in animal models to a brain-wide cellular stress response that’s a common risk factor for dementia. Their findings, published in Nature Communications, could help explain the connection between vision or hearing loss and dementia.
Why do women have more trouble after knee injuries? UTSW model explains
A computer model of the cellular environment inside the knee developed by UT Southwestern Medical Center researchers sheds light on why women tend to have worse outcomes after knee injuries than men. Their findings, published in Scientific Reports, could facilitate research into new therapies for knee inflammatory disorders and personalized treatments for patients with these conditions.
UTSW joins effort to create early screening for dementia
UT Southwestern Medical Center is among 10 U.S. health systems selected for an initiative that aims to create and implement early detection programs for Alzheimer’s disease and other cognitive impairments.
Mood disorders drive feelings of cognitive decline in former college athletes
Former college athletes with a history of concussions were more likely to perceive themselves as cognitively impaired later in life if they had mood disorders such as depression and anxiety – even when testing showed no such decline in mental acuity, a study from UT Southwestern Medical Center researchers has found.
UTSW Research: COVID-19’s effects, brain-computer interfaces, and more
People with multiple sclerosis (MS) are at an increased risk of infection and infection-related hospitalizations, but a study published in Neurology found that being infected with COVID-19 did not significantly affect the course of the disease.
Experimental depression treatment preserves cognitive function
An experimental treatment for depression that triggers seizures with magnets significantly improved mental health in patients without some cognitive effects associated with electroconvulsive therapy (ECT), a clinical trial led by UT Southwestern Medical Center researchers showed.
Study implicates another gene in brain that causes weight gain
Mutations in a gene called OTP cause obesity by controlling the output of another gene already targeted by an anti-obesity drug, a study led by UT Southwestern Medical Center researchers shows.