About Us: O'Donnell Brain Institute Banner - UT Southwestern, Dallas, TX

About Us

The Peter O’Donnell Jr. Brain Institute tackles the most complex problems in the brain. From neurologic diseases, spanning autism to Alzheimer’s, to psychiatric diseases, including addictions and depression, to brain repair strategies for injuries as diverse as stroke and spinal cord trauma, we are embracing the biggest challenges of our time.

What We Offer

Integrated Environment

Integrated Environment

Latest Technologies

Latest Technologies

Mentorship Support

Mentorship Support

A Mission that Spans Research, Education, & Clinical Care

We work to improve the lives of people with neurologic and psychiatric illnesses through:

  • Exceptional clinical care that translates research to the bedside quickly. U.S. News and World Report ranks us among the top neurology and neurosurgery hospitals in the country.
  • Pioneering research in areas from Duchenne muscular dystrophy to Alzheimer’s disease to depression, and much more, that leads directly to improved patient care.
  • High-quality education for tomorrow’s leaders, in a wide variety of areas. Our programs feature mentoring from our expert faculty and access to the latest technologies in brain research and care.

To accomplish our mission, we empower exceptional faculty, trainees, and clinical specialists including diverse researchers Marc Diamond, M.D., Eric Olson, Ph.D., Joseph Takahashi, Ph.D., and Carol Tamminga, M.D. – to pursue their passions.

Genevieve Konopka, Ph.D., wears a white mask and blue gloves while working in her lab
Molecular Pathways Important for Human Brain Evolution

Genevieve Konopka, Ph.D., investigates the molecular pathways important for human brain evolution that are also at risk in cognitive disorders such as autism and Alzheimer’s disease. Her lab uses a combination of human neurons, animal models, and primate comparative genomics to uncover human-specific, disease-relevant patterns of gene expression.

Konopka Lab

Bradley Lega, M.D. works in his lab
Electrophysiology of Human Memory

Bradley Lega, M.D., is co-director of UT Southwestern’s comprehensive epilepsy program and a national expert on the use of stereo EEG to locate the origin of epileptic seizures in the brain. His work examines direct recordings from patients to develop strategies that can improve memory function and restore memory for patients with brain injuries or tumors.

Lega Lab

Joseph Takahashi, Ph.D., looks into a microscope in his lab
Circadian Revelations

Joseph Takahashi, Ph.D., has pioneered the use of forward genetics and positional cloning in the mouse as a tool for discovery of genes underlying neurobiology and behavior. His discovery of the mouse and human clock genes led to a description of a conserved circadian clock mechanism in animals.

Takahashi Lab

Carol Tamminga, M.D.
The Biology of Psychoses

Carol Tamminga, M.D., leads the Division of Translational Neuroscience in Schizophrenia with the goal of understanding the pathophysiology of schizophrenia and related disorders. The group’s research explores how the brain makes a hallucination or a delusion, and is providing insight at the cellular and synaptic levels.

Tamminga Lab

Madhukar Trivedi, M.D., talks to a male patient who sits in a chair
Taking the Guesswork Out of Depression Treatment

Madhukar Trivedi, M.D., and his team focus on pharmacological, psychosocial, and nonpharmacological treatments for depression. Dr. Trivedi, Director of the Center for Depression Research and Clinical Care leads a national trial that has produced what scientists are calling the project’s flagship finding: a computer that can accurately predict whether an antidepressant will work based on a patient’s brain activity.

Trivedi Lab